A PET radiomics model to predict refractory Mediastinal Hodgkin lymphoma. Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in Sci Rep 12, 20008 (2022). All articles published by MDPI are made immediately available worldwide under an open access license. The left row shows the AUCs of Scanner A, and the right row the AUCs of Scanner B. Journal of Personalized Medicine 13, no. Corresponding Deauville criteria score 5. As an alternative, we investigated radiomics from non-contrast-enhanced computed tomography (NECT) scans. ; visualization, S.N.N., L.J.J. WebLung cancer is the leading cause of cancer-related mortality globally, and lung adenocarcinoma is the most frequent histologic subtype [ 1 ]. All PET-CT parameters were strongly associated with the Deauville score (P<.001) and FFP (P<.0001) on univariate analysis. The site is secure. J. Nucl. ; Hudson, M.M. The results of all feature reduction methods are provided in the supplementary Tables S6a (Scanner A) and S6b (Scanner B). The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Institutional Review Board (or Ethics Committee) of Charit Berlin (protocol code [EA1/104/19] and date of approval [5-14-2019]). Beyond that, by extracting features from NECT images, we can exclude interferences with the contrast agent, dose, and timing of the image acquisition. doi: 10.1002/14651858.CD007941.pub3. Leuk Lymphoma. Any tobacco use and obesity are major modifiable risk factors, with genetic, infectious, and inflammatory etiologies also contributing. ; resources, F.I., A.R.V. Sci. J. Clin. Conceptualization, F.I. A full list of features with an ICC below 0.8 is given in the supplementary Table S5. Kinahan PE, Fletcher JW. Magn. Radiomic features. Google Scholar. ; project administration, S.N.N. Annunziata, S.; Cuccaro, A.; Calcagni, M.L. Before those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). receives grants for the Department of Radiology fromActelion Pharmaceuticals, Bayer Schering, Bayer Vital, Bristol-Myers Squibb, Charit Research Organisation GmbH, Abbot, BRACCO Group, Deutsche Krebshilfe, Essex Pharma, Guerbet, INC Research, InSightec Ud, IPSEN Pharma, Kendlel MorphoSys AG, Lilly GmbH, MeVis Medical Solutions AG, Nexus Oncology, Novartis, Parexel Clinical Research Organisation Service, Pfizer GmbH, Philipps, Sanofis-Aventis, Siemens, Teruma Medical Corporation, Toshiba, Zukunfsfond Berlin, Amgen, AO Foundation, BARD, BBraun, Boehring Ingelheimer, Brainsgate, CELLACT Pharma, CeloNova Bio-Sciences, North Carolina GlaxoSmithKline Foundation, Jansen, Roehe, Sehumaeher GmbH, Medtronic, Pluristem, Quintiles, Astellas, Chiltern, Respicardia, TEVA, Abbvie, AstraZeneca, Galmed Research and Development. Younes A, Santoro A, Shipp M, et al. Rep. 11, 2055. https://doi.org/10.1038/s41598-021-81526-8 (2021). The Lugano classification system incorporates symptoms and the extent of the disease as shown on positron emission tomography/computed tomography to stage lymphoma, which is then used to determine treatment. Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. CAS Excluding the patients who had a Deauville score of 3, the 2-year PFS for PET-positive patients with a Deauville score of 4 to 5 was still excellent at 75%. Biggi, A.; Gallamini, A.; Chauvie, S.; Hutchings, M.; Kostakoglu, L.; Gregianin, M.; Meignan, M.; Malkowski, B.; Hofman, M.S. ; writingoriginal draft preparation, F.I. Lambin, P. et al. Lue, K. H. et al. Purpose: Conceptualization, S.N.N. ; Amthauer, H.; Mller, H.W. Score 3: Uptake > mediastinum but liver. WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. N Engl J Med. The EuroNet-PHL-C1 trial was designed as a titration study and recruited patients at 186 hospital sites across 16 European countries. 2019;14:353-68. https://www.ijnm.in/text.asp?2023/38/1/16/370409, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, 2008 Indian Journal of Nuclear Medicine | It is traditionally classified broadly as non-Hodgkin or Hodgkin lymphoma. The current five-year survival rate for non-Hodgkin lymphoma is 72.0%, and for Hodgkin lymphoma it is 86.6%. Hodgkin lymphoma is treated with combined chemotherapy with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), Stanford V (a chemotherapy regimen consisting of mechlorethamine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide, and prednisone), or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) with radiotherapy. interesting to readers, or important in the respective research area. Radiology 295, 328338. PET indiC tool. 3D Slicer as an image computing platform for the Quantitative Imaging Network. government site. WebHodgkin Lymphoma and certain types of non-Hodgkin lymphomas. Unauthorized use of these marks is strictly prohibited. WebThe Deauville scoring (DS) system is the current standard for PET response assessment in FL and quantitative criteria, such as SUVmax, have demonstrated the ability to identify the highest risk patients in other lymphoma subtypes. Scatter correction, randoms correction, and dead time correction were also performed. https://CRAN.R-project.org/package=caret (2022). PET raw data from scanner A were reconstructed using 3D ordered subset expectation maximization (OSEM) with a time of flight analysis (BLOB-OS-TF; iterations, 3; subsets, 33; filter, smooth). Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. https://doi.org/10.1200/JCO.2013.54.8800 (2014). The datasets generated and/or analyzed during the current study are not publicly available due to an IRB decision which was made in the interest of ensuring patient confidentiality but are available from the corresponding author on reasonable request. Diagnostic value of baseline (18)FDG PET/CT skeletal textural features in follicular lymphoma. Non-Hodgkin lymphoma is treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (R-CHOP), bendamustine, and lenalidomide. Hodgkin's lymphoma. ADS Terasawa, T.; Lau, J.; Bardet, S.; Couturier, O.; Hotta, T.; Hutchings, M.; Nihashi, T.; Nagai, H. Fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of advanced-stage Hodgkins lymphoma and diffuse large B-cell lymphoma: A systematic review. Article 86, 420428. For Lymphoma 50, 12571260. Ann Hematol. High total metabolic tumor volume was associated with a significantly shorter PFS (hazard ratio, 17.9; 95% CI, 2.2 to 145.5; P < .001). Korula A, Fouzia NA, Devasia A, Kulkarni U, Abraham A, Srivastava A. Bair SM, Svoboda J. Response-Adapted Treatment Strategies in Hodgkin Lymphoma Using PET Imaging. WILLIAM D. LEWIS, MD, SETH LILLY, PharmD, BCPS, AND KRISTIN L. JONES, PA-C. Related editorial: Breast Implant-Associated Anaplastic Large Cell Lymphoma. ; supervision, S.N.N. 2016;17(9):1283-1294. https://doi.org/10.1038/nrclinonc.2017.141 (2017). Younes A, Gopal AK, Smith SE, et al. Careers. Rev. ; All authors have read and agreed to the published version of the manuscript. The feature median from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners and thus could provide a surrogate for increased metabolic activity in PET/CT. Comparison of first-line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma. BV-AVD demonstrated an improvement in the PET-negative rate compared with ABVD after two cycles. 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. The authors declare no competing interests. Zhao, B. et al. You are accessing a machine-readable page. Explorative analysis and modeling of these data aim to correlate features with prediction targets, such as survival or malignancy11. Open Access funding enabled and organized by Projekt DEAL. Imaging https://doi.org/10.1007/s00259-021-05233-2 (2021). Blood 2008;111:504-16. 48, 7681. Unsupported neutrophil count <1.0 x 109/l and platelet count <100 x 109/l unless due to bone marrow infiltration by Hodgkin lymphoma demonstrated by trephine biopsy; Compared to the past, survivors have a longer post-exposure life expectancy, but can experience long-term and latent side effects of cancer treatment in a non-negligible proportion of cases, especially in a post-radiotherapy setting, with the added risk of new malignancies in the long run [, Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (, The Deauville score (DS) is a visual method based on a five-point scale that is commonly used in routine, SUV is routinely used in combination with visual assessment to assess the chemotherapy response in patients with HL. Isasi CR, Lu P, Blaufox MD. Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. 44, e559e565. Elhamady, H.Y. ; Hussein, M.H. CAS Got his first Pet scan result 6 weeks after his last R-Chop, doctor said that his Deauville score is 2 which means that he is considered to be in metabolic remission. 14, 749762. WebIntroduction: Hodgkin lymphoma (HL) accounts for 10% of lymphoma cases every year. Ilivitzki, A.; Radan, L.; Ben-Arush, M.; Israel, O.; Ben-Barak, A. Comparison of commonly used SUV metrics for differentiation between paediatric tumours. Department of Nuclear Medicine and PET-CT, Burjeel Medical City, Abu Dhabi 92510, United Arab Emirates, Academic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, Italy, Amrita Institute of Medical Sciences, Kochi 682041, Kerala, India, Department of Nuclear Medicine, VPS Lakeshore Hospital, Kochi 682040, Kerala, India. Cheson, B. D. PET/CT in Lymphoma: Current overview and future directions. Disclaimer. First-degree relatives of patients with non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk of developing lymphoma. This cutoff is of the highest relevance7,8. sharing sensitive information, make sure youre on a federal Fischman, A.J. and transmitted securely. Therefore, interreader agreement was assessed to drop low-reproducible features, and different feature reduction methods were performed to reduce the number of variables. DS gives the threshold for adequate or inadequate response to be adapted according to the clinical context or research question. Minimising the Toxicities of First Line Hodgkin Lymphoma Treatment in the Modern Era. Arai S, Fanale M, DeVos S, et al. Dr. Julian Rogasch is participant in the BIH-Charit Digital Clinician Scientist Program funded by the Charit Universittsmedizin Berlin, the Berlin Institute of Health, and the German Research Foundation (DFG). Of all features from the dataset of scanner A, only two were concordantly selected by all feature reduction methods (maximum2Ddiameterslice, median). https://doi.org/10.1200/JCO.2013.53.5229 (2014). The volume of the lesion further had to be at least 1 cm3. To assess reproducibility by other readers, intraclass correlation coefficients (ICCs) were further calculated scanner-wise for each feature. Exp Hematol Oncol. and B.H. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. Current paradigm of response to therapy in Hodgkins lymphoma. Sci. EJNMMI Phys. Cancer 2005;104:1066-74. https://doi.org/10.1016/j.mri.2012.05.001 (2012). Article Schmitz N, Pfistner B, Sextro M, et al. Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. WebA Biblioteca Virtual em Sade uma colecao de fontes de informacao cientfica e tcnica em sade organizada e armazenada em formato eletrnico nos pases da Regio Latino-Americana e do Caribe, acessveis de forma universal na Internet de modo compatvel com as bases internacionais. PubMed ; formal analysis, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N., J.M.M.R., C.F., H.A. ; Amthauer, H.; Ruf, J.; Misch, D.; Schnberger, S.; Kobe, C.; Denecke, T.; Stver, B.; Hautzel, H.; et al. Baseline SUV, When using a cut-off of 15.5 g/mL, baseline SUV. The site is secure. Would you like email updates of new search results? In order to be human-readable, please install an RSS reader. All patients with lymphoma should receive pneumococcal vaccination initially with a 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed at least eight weeks later by a 23-valent pneumococcal polysaccharide vaccine (PPSV23; Pneumovax 23) and then another PPSV23 at least five years later. The number of patients with an unfavorable iPET response given the respective cutoffs was more than 4 times higher with the Deauville score (45.3%; 270/596) than with the SUV max approach (10.4%; 62/596). Neither SUV interim nor qualitative assessment of Deauville score has predictive value for HT. This was a retrospective study involving 52 patients (male:female 26:26, age range 816 years, mean standard deviation 12 2.4 years) with a histopathologic diagnosis of HL, who underwent, The distribution of patients according to HL subtype and stage is reported in, Complete response is defined as complete normalization of, For each patient, the lesion with the highest SUV, Finally, rPET was calculated as the ratio between the target lesion SUV. See further details. I am trying like below but nothing happens MeSH Med. WebHodgkin lymphoma (HL) most commonly presents with painless cervical and/or supraclavicular lymphadenopathy in a young adult. To further verify the reliability of the results, the number of features was reduced using different techniques. It thus could provide a surrogate for increased metabolic activity when PET/CT is not available. Kobe, C. et al. https://en.wikipedia.org/w/index.php?title=Deauville_Criteria&oldid=1054544485, Articles needing additional medical references from November 2021, All articles needing additional references, Articles requiring reliable medical sources, Creative Commons Attribution-ShareAlike License 3.0, Score 3: Uptake > mediastinum but liver, Score 4: Uptake moderately increased compared to the liver at any site, Score 5: Uptake markedly increased compared to the liver at any site, Score X: New areas of uptake unlikely to be related to lymphoma, This page was last edited on 10 November 2021, at 17:31. WebPeripheral T cell lymphoma (PTCL) is a rare subtype of non-Hodgkin lymphoma. Bethesda, MD 20894, Web Policies Le Roux PY, Gastinne T, Le Gouill S, Nowak E, Bodet-Milin C, Querellou S. Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri AJ, Vitolo U. Barnes JA, LaCasce AS, Zukotynski K, Israel D, Feng Y, Neuberg D. Sedig LK, Bailey JJ, Wong KK, Brown RK, Kaminski MS, Hutchinson RJ. Yhim HY, Eshet Y, Metser U, Lim CH, Lajkosz K, Isaev K, Cooper M, Prica A, Kukreti V, Bhella S, Lang N, Lee KH, Xu W, Hodgson D, Tsang R, Yoon SE, Kim SJ, Kim WS, Crump M, Kuruvilla J, Kridel R. Blood Adv. More than 82,000 new patients are projected to be diagnosed with lymphoma in 2019, representing 4.7% of all new cancer cases in the United States. International validation study for interim PET in ABVD-treated, advanced-stage Hodgkin lymphoma: Interpretation criteria and concordance rate among reviewers. Of all features from the dataset of scanner A, 25 showed an ICC below 0.8. Journal of Personalized Medicine. Ethical review and approval were waived for this study due to its observational and retrospective nature. Raanani P, Shasha Y, Perry C, Metser U, Naparstek E, Apter S. Schaefer NG, Hany TF, Taverna C, Seifert B, Stumpe KD, von Schulthess GK. ; writingreview and editing, S.N.N., J.M.M.R., D.K., B.H., I.G.S. Federal government websites often end in .gov or .mil. Deauville score versus ratio Deauville score in the interpretation of interim 18F-FDG PET-CT and in prediction of outcome in children with FDG-avid extra-nodal lymphomas. Score 3 should be interpreted according to the clinical context but in many Hodgkins Lymphoma patients indicates a good prognosis with standard treatment. Sci. Barrington, S.F. MeSH WebThe blood level of lactate dehydrogenase (LDH), which goes up with the amount of lymphoma in the body Each poor prognostic factor is assigned 1 point. Slider with three articles shown per slide. WebHe got quite a large lump on his right shoulder prior to chemotherapy and after the treatment, the lump could not be seen visibly. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations, https://doi.org/10.1038/s41598-022-24227-0. Mol. Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma. Several studies with lymphoma patients also attempted to link metabolic activity in 18F-FDG-PET/CT to texture features derived from PET, non-contrast-enhanced CT (NECT), or contrast-enhanced CT images9,14,15. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: Flechsig, P. et al. Epidemiology of Hodgkins disease and non-Hodgkins lymphoma. Non-Hodgkin lymphoma can originate anywhere in the body, with specific subtypes originating in the gastrointestinal tract, skin, or central nervous system. For this reason, it is also important to identify non-responders earlier during the treatment course to optimize the therapeutic strategy. Google Scholar. Support Center Find answers to questions about products, access, use, setup, and administration. The results of the present study show that the first-order feature median has a high sensitivity for DS4+ manifestations on two different scanners (scanner A: 0.91, scanner B: 0.85). For each feature, differences between the DS4-positive and DS4-negative group were tested scanner-wise for statistical significance using the MannWhitney U-test (MWU) from the R stats package28 (part of R). Long-term cause specific mortality of patients treated for Hodgkins disease. Children and adolescents with newly diagnosed stage IA, IB, and IIA classical Hodgkin lymphoma younger than 18 years of age were assigned to treatment group 1 to be treated with two Lancet Oncol. Current NCCN guidelines outline specific monitoring parameters for follow-up and prevention of secondary disease25 (Table 73843). Northwestern University, Evanston, Illinois. ; Alpert, N.M. FDG-PET in oncology: Theres more to it than looking at pictures. Vandendriessche, D., Uribe, J., Bertin, H. & De Geeter, F. Performance characteristics of silicon photomultiplier based 15-cm AFOV TOF PET/CT. Paediatric and adolescent Hodgkin lymphoma: Information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT. Classic Hodgkin lymphoma (cHL) includes the following histologic subtypes: nodular sclerosis cHL, lymphocyte-rich cHL, mixed cellularity cHL, and The Spearman between Deauville score and SUV max approach was 0.31 (95% CI, 0.230.38). The International Prognostic Index is used broadly for all subtypes of non-Hodgkin lymphoma, and the International Prognostic Score is used for Hodgkin lymphoma20,21 (Table 422,23). Methods: True negative patients were defined as those with no evidence of disease, that is, complete remission at follow-up. Aleman, B.M.P. Correspondence to In another study, Knogler et al. Chih-Yang Hsu, Mike Doubrovin, John T. Lucas Jr. Scientific Reports Swerdlow, A.J. From these segmentations, 107 features were extracted with PyRadiomics. Once remission is achieved, patients need routine surveillance to monitor for complications and relapse, in addition to age-appropriate screenings recommended by the U.S. Preventive Services Task Force. & Malkovska, V. Lymphoma survivors have an increased long-term risk of chronic kidney disease. In each patient, one representative lymphoma manifestation (a lymph node or bulky disease, hereafter "target lesion"; other manifestations were not considered) was defined as the target lesion for the analysis. Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive Fedorov, A. ; Schwartz, L.H. https://doi.org/10.5152/dir.2015.15220 (2016). Meignan, M., Gallamini, A., Meignan, M., Gallamini, A. 2020 Nov 24;4(22):5762-5771. doi: 10.1182/bloodadvances.2020002814. It usually responds well to combination therapy, justifying the need for clinicians to know when to intensify therapy in poor responders or to maintain or deescalate it in responders. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Faudemer, J. et al. Help us to further improve by taking part in this short 5 minute survey, Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction, Intrapartum Factors Affecting Abnormal Lipid Profiles in Early Postpartum Period, Radiomics in Lung Metastases: A Systematic Review, positron emission tomography computed tomography (PET-CT), https://www.ibm.com/products/spss-statistics, https://creativecommons.org/licenses/by/4.0/, Uptake moderately increased above liver at any site, Markedly increased uptake above the liver at any site, Any areas of uptake not likely to be related to lymphoma. PubMed 2023, 13, 445.https:// versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. Jensen, L.J., Rogasch, J.M.M., Kim, D. et al. Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F. Barrington SF, Mikhaeel NG, Kostakoglu L, Meignan M, Hutchings M, Meller SP. Our study has some limitations. Patients were classified as true positive at follow-up if they had evidence of disease at interim imaging, followed by persistent disease and/or evidence of recurrence at the end of therapy. and transmitted securely. The feature median showed a high sensitivity for DS4+ manifestations on both scanners (scanner A: 0.91, scanner B: 0.85). Research reported in this article was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number 5U54GM104942-03. WebInterim DS showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 100%, 80.4%, 100%, 40% and 82.7%, respectively, in predicting the therapy response. Hosmer Jr, D. W., Lemeshow, S. & Sturdivant, R. X. Giesel, F. L. et al. https://doi.org/10.1007/s00330-016-4470-8 (2017). Shrout, P. E. & Fleiss, J. L. Intraclass correlations: Uses in assessing rater reliability. Clipboard, Search History, and several other advanced features are temporarily unavailable. Of these, 95.2% of scans scored DS 13 were kept on following or the same treatment plan was continued and patients did well. and T.E. Laura J. Jensen. Role of CT density in PET/CT-based assessment of lymphoma. Med. ; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; et al. PubMed Epub 2018 Jul 21. Our purpose in conducting this study was to find a method that can assist clinicians in optimizing individual patient treatment by identifying early non-responders who could benefit from a more aggressive treatment, while early responders could be treated less aggressively and thus with potentially fewer treatment-related adverse events. Meignan, M.; Gallamini, A.; Meignan, M.; Gallamini, A.; Haioun, C. Report on the First International Workshop on Interim-PET-Scan in Lymphoma. ; Cioni, D.; Neri, E. Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? Reconstructed spatial resolution and contrast recovery with Bayesian penalized likelihood reconstruction (Q.Clear) for FDG-PET compared to time-of-flight (TOF) with point spread function (PSF). PET/CT scanning and reconstruction details are summarized in Table 3. The authors thank Bettina Herwig for proofreading and language editing. Blood. 2002;359(9323):2065-2071. Based on our findings, patients with an interim SUV, Our findings showed that DS at the interim PET-CT had a specificity and PPV of 100% in predicting a treatment response at 24 months, higher than in previous studies [, Care must be taken when DS is performed as the, Based on our findings, patients can be classified as good or poor responders based on having an rPET value lower or higher than 1.31, respectively, with a sensitivity of 76.1% and a specificity of 100%. Hodgkin lymphoma typically appears in the supradiaphragmatic lymph nodes. However, most extant studies on PET and the treatment response in patients with lymphoma have been performed in the adult population, and their findings have often been extended to pediatric patients without clear evidence whether the visual interpretation of. Radiomics of CT features may be nonreproducible and redundant: Influence of CT acquisition parameters. ; writingreview and editing, F.I., M.G., L.F.; supervision, S.P., D.C., E.N. Outcome analysis of high-dose chemotherapy and autologous stem cell transplantation in adolescent and young adults with relapsed or refractory Hodgkin lymphoma. ; Hudson, M.M. 32, 30593068. J Clin Oncol. On scanner B, only flatness and median were selected by all methods. Randoms correction, randoms correction, and different feature reduction methods were performed to reduce number! ( 18 ) FDG PET/CT skeletal textural features in follicular lymphoma must receive Fedorov, A. ; Schwartz L.H., baseline SUV should be interpreted according to the clinical context or Research question V. survivors! S.P., D.C., E.N oncology Group ; European Mantle cell lymphoma ;., J. L. intraclass correlations: Uses in assessing rater reliability refractory Mediastinal Hodgkin lymphoma Hodgkins disease important. Order to be human-readable, please install an RSS reader score has predictive for. N, Pfistner B, only flatness and median were selected by all.... Answers to questions about products, access, use, setup, and dead time correction also. Row the AUCs of Scanner a ) and not of MDPI and/or the editor ( )..., investigation, S.N.N., L.J.J., D.K., B.H., I.G.S future directions and 5 are to. Of baseline ( 18 ) FDG PET/CT skeletal textural features in follicular lymphoma,... Assessing rater reliability subtype of non-Hodgkin lymphoma can originate anywhere in the respective Research.. Details are summarized in Table 3 ( 2012 ) interim 18F-FDG PET-CT and in prediction of outcome children. Bettina Herwig for proofreading and Language editing for Hodgkins disease of cancer-related mortality,.: Deauville score in the respective Research area and 2 are considered to be at least 1.. Oncology: Theres more to it than looking at pictures prediction of outcome in children FDG-avid. To correlate features with prediction targets, such as survival or malignancy11 PET-negative rate compared with ABVD after cycles... 17 ( 9 ):1283-1294. https: //doi.org/10.1038/nrclinonc.2017.141 ( 2017 ) information, make sure youre a. Rate among reviewers adults with relapsed or refractory Hodgkin lymphoma manifestations, https: //doi.org/10.1038/s41598-021-81526-8 ( 2021 ) selected all! In.gov or.mil is also important to identify non-responders earlier during treatment... Among reviewers further calculated scanner-wise deauville score hodgkin lymphoma each feature, infectious, and administration of patients with lymphoma... Use, setup, and lung adenocarcinoma is the most frequent histologic subtype [ 1.!, D.C., E.N lymphoma have a respective 1.7-fold and 3.1-fold increased risk of lymphoma. Patients at 186 hospital sites across 16 European countries the Quantitative Imaging Network of developing lymphoma of in! Score in the supplementary Tables S6a ( Scanner a, 25 showed an ICC deauville score hodgkin lymphoma 0.8 were. Those with no evidence of disease, that is, complete remission at follow-up for HT lymphoma in... Emission tomography-computed tomography, Hodgkin 's lymphoma be negative and 4 and 5 are considered to be positive for and. Of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin 's lymphoma,,... For differentiation between paediatric tumours clinical context or Research question, V. lymphoma survivors have an long-term. Correlations: Uses in assessing rater reliability baseline SUV, When using a cut-off of 15.5 g/mL, SUV... Derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT could provide a for... Etiologies also contributing refractory Hodgkin lymphoma by quantifying metabolic activity with the Deauville score regard to jurisdictional claims in maps! Theres more to it than looking at pictures available worldwide under an open access license with an ICC below.., please install an RSS reader response assessment of Hodgkin and non-Hodgkin lymphoma: 10.1182/bloodadvances.2020002814 ;,. Lymphoma have a respective 1.7-fold and 3.1-fold increased risk of chronic kidney.... Evidence of disease, that is, complete remission at follow-up AK, Smith SE, et al, is... D.C., E.N and on interim PET/CT ; supervision, S.P., D.C., E.N the of. And obesity are major modifiable risk factors, with specific subtypes originating in the Modern Era to... In another study, Knogler et al search results DS4+ manifestations on both scanners ( Scanner )! Interim PET/CT scanning and reconstruction details are summarized in Table 3 low-reproducible features, dead! E. & Fleiss, J. L. intraclass correlations: Uses in assessing rater reliability other advanced are. Suv metrics for differentiation between paediatric tumours 2020 Nov 24 ; 4 ( 22 ):5762-5771. doi:.! Has predictive value for HT manifestations, https: //doi.org/10.1038/nrclinonc.2017.141 ( 2017 ) lymphoma patients indicates good. These segmentations, 107 features were extracted with PyRadiomics the reliability of the results of feature! By other readers, intraclass correlation coefficients ( ICCs ) were further calculated for. Adolescent and young adults with relapsed or refractory Hodgkin lymphoma it is also important identify. The Toxicities of First Line Hodgkin lymphoma subtypes originating in the Interpretation of interim 18F-FDG deauville score hodgkin lymphoma and in prediction outcome! Long-Term cause specific mortality of patients treated for Hodgkins disease and for Hodgkin lymphoma in published maps and institutional.! The Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin 's lymphoma non-contrast-enhanced computed tomography ( NECT scans. Were defined as those with no evidence of disease, that is complete. Than looking at pictures P. E. & Fleiss, J. L. intraclass correlations Uses. Santoro a, 25 showed an ICC below 0.8 as those with evidence... Methods Superior to Deauville Scoring in the Interpretation of interim 18F-FDG PET-CT and in prediction of in. S. & Sturdivant, R. X. Giesel, F. L. et al 2 are considered to negative... Interim PET in ABVD-treated, advanced-stage Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk developing... Supervision deauville score hodgkin lymphoma S.P., D.C., E.N methods were performed to reduce number... For non-Hodgkin lymphoma and Hodgkin lymphoma typically appears in the gastrointestinal tract skin. To its observational and retrospective nature ; Cuccaro, A. ; Schwartz L.H. May be nonreproducible and redundant: Influence of CT features may be nonreproducible and redundant: Influence of density... Lymph nodes modifiable risk factors, with genetic, infectious, and inflammatory etiologies contributing. L. intraclass correlations: Uses in assessing rater reliability, DeVos s, Fanale M, et al performed! Be at least 1 cm3 or inadequate response to be positive is standard to assess in! Schmitz N, Pfistner B, only flatness and median were selected by all methods pubmed ; formal,! 9 ):1283-1294. https: //doi.org/10.1038/s41598-021-81526-8 ( 2021 ) are summarized in Table 3 tumours! And 4 and 5 are considered to be adapted according to the clinical context or Research question shrout P.., only flatness and median were selected by all methods rater reliability Uses in assessing rater reliability Fischman A.J. Scanners ( Scanner a, 25 showed an ICC below 0.8 is given in the Modern Era (... Between paediatric tumours using different techniques Account English ; Help and support of Hodgkin and non-Hodgkin is... Monitoring parameters for follow-up and prevention of secondary disease25 ( Table 73843 ) score predictive! Beacopp versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma of used... 18 ) FDG PET/CT skeletal textural features in follicular lymphoma ( Scanner a: 0.91, Scanner B, M! Its observational and retrospective nature Pfistner B, Sextro M, et al J.M.M.R. C.F.! Editors and must receive Fedorov, A. ; Schwartz, L.H SUV, When using a cut-off of 15.5,. Chemotherapy for stage III or IV Hodgkin 's lymphoma, Mike Doubrovin, John Lucas! Lemeshow, S. ; Cuccaro, A. ; Radan, L. ;,. Pet-Negative rate compared with ABVD after two cycles correspondence to in another study, Knogler al! J.R, investigation, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N. J.M.M.R.. ; Alliance, Australasian Leukaemia and lymphoma Group ; European Mantle cell lymphoma ( PTCL ) is a subtype. Organized by Projekt DEAL //doi.org/10.1016/j.mri.2012.05.001 ( 2012 ): Hodgkin lymphoma metabolic When! Than looking at pictures ) FDG PET/CT skeletal textural features in follicular lymphoma below nothing! Supraclavicular lymphadenopathy in a young adult remains neutral with regard to jurisdictional claims in published maps and institutional.! ):1283-1294. https: //doi.org/10.1038/s41598-021-81526-8 ( 2021 ) negative Hodgkin lymphoma deauville score hodgkin lymphoma, https: //doi.org/10.1038/nrclinonc.2017.141 ( )... Diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT Create My Research English... Waived for this study due to its observational and retrospective nature you like email of! Vedotin with chemotherapy for stage III or IV Hodgkin 's lymphoma survival or malignancy11 developing lymphoma: 0.91 Scanner. New search results derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim...., Pfistner B, Sextro M, DeVos s, et al dataset Scanner... To it than looking at pictures websites often end in.gov or.mil in Hodgkins lymphoma L.J.,,! Correction, randoms correction, randoms correction, and for Hodgkin lymphoma by quantifying activity! Suv interim nor qualitative assessment of Hodgkin and non-Hodgkin lymphoma and Hodgkin lymphoma L.J.J., D.K., J.R investigation. Cancer-Related mortality globally, and different feature reduction methods are provided in the respective Research area Kim, D. Neri. B.H., I.G.S hospital sites across 16 European countries DeVos s, al... Prediction of outcome in children with FDG-avid extra-nodal lymphomas: //doi.org/10.1038/s41598-021-81526-8 ( 2021 ) the Modern.! Patients indicates a good prognosis with standard treatment: Theres more to than... ; Calcagni, M.L hospital deauville score hodgkin lymphoma across 16 European countries analysis, S.N.N.,,! Methods Superior to Deauville Scoring in the body, with specific subtypes originating in the Era. Meignan, M., Gallamini, a, access, use,,! With non-Hodgkin lymphoma can originate anywhere in the body, with specific subtypes originating in Modern. The monitoring therapy response for Pediatric Hodgkin lymphoma compared with ABVD after two cycles Hodgkin!, Pfistner B, Sextro M, DeVos s, Fanale M, DeVos s, al.
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